@fredisback81 said in MAME - Gamepad PS3 - how-to buttons config?:

Or what is the idea, that each ROM has to be configured on its own (e.g. within Retroarch / Op
tions / Input configuration ?)

You can customize the controls via the Retroarch menu as you mentioned, it is possible to save a configuration by core or by game, as you prefer.
Another option is to try this with Configuration overload:
https://recalbox.gitbook.io/documentation/advanced-user/configuration/configuration-overload

Au temps pour moi, il faut à la fois activer le driver pour la Xbox et à la fois désactiver celui de la PS3.