Ok I think I have it figured out but I also messed something up. I'll try to post a tutorial for how to do controls for a specific game, if there isn't one already.

In the meantime, I messed something up where with one of the games I was messing with I no longer have access to my hotkey. I also no longer have access to mames config menu (pressing tab while in a game).

The hotkey and the mame config menu all work in other games.

So what did I do and how do I fix this?

When I load the problem rom there isn't any indication that a configuration file was loaded or overridden. So how can I delete any config files that might have been created for this game?

@voljega
Thanks for your proposal. Concerning DOS, I am in general a freak of isometric games.Because of limited time, I concentrate on this category. For the moment I own all of the games in the time they came out, and frankly, most are cheap also from GOG.
I want to give a try to another pearl "Lara Croft and the Guardian of Light". If possible.

@sibobbbe If you have Windows, you should try UXS.
https://forum.recalbox.com/topic/4690/soft-universal-xml-scraper-v2/100