@nordicpower try activating the Joypad to Keyboard option in Retroarch‘s menu (arrow) and pressing SELECT on your gamepad to simulate the ESC key press.

http://docs.libretro.com/library/neko_project_ii_kai/#controllers

@Colin-Williams why not use hotkey instead of esc ?
And why the enter button ? Computer games ?

Thank you for the prompt reply. Appreciate it!! Problem solved

Bonjour Je viens de lire vos messages. Dans le cas d'avoir un bouton hotkey,sur quel numéro doit-on le mettre sur le gpio ? Merci d'avance