@nordicpower try activating the Joypad to Keyboard option in Retroarch‘s menu (arrow) and pressing SELECT on your gamepad to simulate the ESC key press.

http://docs.libretro.com/library/neko_project_ii_kai/#controllers

@Tornelf
regarde dans retroarch si il y a l option Disk Swap Interface et teste à partir de là
Pas eu le temps de tester.