@Nerces44 I use a NESPiCase4 with a SSD Disk. All my stuff (recalbox & roms) are on the SSD and I have no problem. Perhaps, that's an issue from your power adapter (not enough ampere) or an issue from your sata bridge firmware. I had to change the firmware for booting from ssd. Since I've done that my sata bridge seems to be more efficient (see http://download.retroflag.com/Products/NESPi_4_CASE/How_to_boot_from_SSD.zip).
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RE: [Recalbox 7.0.1] Nespi 4 - Recalbox freezes when using the SSD