I'm having serious issues with Ginga Fukei Densetsu - Sapphire (NTSC-J), and Super Daisenryaku (NTSC-J) and they just do not work.

I do not have a head as hard as Bonks
ISO AND CUE FILES
I found it to be a problem with the ISO file, I checked the CUE files, I downloaded these games on several sites, I opened an issue in github and in the end @acris helped me and sent me the ISO that I had and it's the same as I have and anyway did not work.
Since she suspects the BIOS now, since all other games work except these two.
ISO
Ginga_Fukei_Densetsu_-_Sapphire_(NTSC-J)_[HCD5080].iso
renamed Saphire.iso
CUE
| FILE "Sapphire.iso" BINARY |
| TRACK 01 AUDIO |
| INDEX 01 00:00:00 |
| TRACK 02 MODE1/2352 |
| PREGAP 00:03:00 |
| INDEX 01 00:44:65 |
| TRACK 03 AUDIO |
| PREGAP 00:02:00 |
| INDEX 01 02:26:14 |
| TRACK 04 AUDIO |
| INDEX 00 06:27:70 |
| INDEX 01 06:27:73 |
| TRACK 05 AUDIO |
| INDEX 00 10:30:42 |
| INDEX 01 10:30:45 |
| TRACK 06 AUDIO |
| INDEX 00 14:32:26 |
| INDEX 01 14:32:29 |
| TRACK 07 AUDIO |
| INDEX 00 18:34:45 |
| INDEX 01 18:34:48 |
| TRACK 08 AUDIO |
| INDEX 00 22:37:23 |
| INDEX 01 22:37:26 |
| TRACK 09 AUDIO |
| INDEX 00 24:38:72 |
| INDEX 01 24:39:00 |
| TRACK 10 AUDIO |
| INDEX 00 26:41:71 |
| INDEX 01 26:41:74 |
| TRACK 11 AUDIO |
| INDEX 00 28:43:34 |
| INDEX 01 28:43:37 |
| TRACK 12 AUDIO |
| INDEX 00 29:16:61 |
| INDEX 01 29:16:64 |
| TRACK 13 AUDIO |
| INDEX 00 29:49:46 |
| INDEX 01 29:49:49 |
| TRACK 14 AUDIO |
| INDEX 00 30:51:23 |
| INDEX 01 30:51:26 |
| TRACK 15 AUDIO |
| INDEX 00 32:03:30 |
| INDEX 01 32:03:33 |
| TRACK 16 AUDIO |
| INDEX 00 33:33:04 |
| INDEX 01 33:33:07 |
| TRACK 17 MODE1/2352 |
| PREGAP 00:03:00 |
| INDEX 01 36:45:31 |
MD5
I checked the md5 of the syscard3.pce
BIOS file its MD5 is ff1a674273fe3540ccef576376407d1d
and is OK. (You can do the test here: http://onlinemd5.com/)
BIOS
Even if I changed the BIOS for the ones I downloaded and the games were still not working, I decided to test the 2.0 and 1.0 versions of the BIOS.
Version 1.0
BIOS screen

And loading the game appears NOW LOADING IN THE GAME and returns to the ES.
Version 2.1
BIOS screen

and loading the game appears this image I believe it is to put the supercard, or something like (I do not understand anything Japanese)

Version 3.0
Which is the indicated BIOS version displays your BIOS screen
And loading the game appears NOW NOW LOADING and returns to the ES.
REFERENCE
https://github.com/recalbox/recalbox-os/wiki/Add-system-bios-(EN)
https://forums.libretro.com/t/mednafen-pce-turbografx-cd-vs-super-cd-rom-2-bios-screens/5700
https://github.com/libretro/Lakka/wiki/BIOSes
https://github.com/RetroPie/RetroPie-Setup/wiki/PC-Engine
https://retropie.org.uk/forum/topic/7564/turbografx-16-only-a-few-roms-running <-- This had the same problem that I am having being with other games and did not see how it was solved.
HELP ME
Who can help me, see if these games run on their recalbox and report the following:
Recalbox Version: (4.0 or 4.1 unstable)
Hardware: (rpi2, rpi3, odroid or pc)
Core Emulator:
MD5 Bios:
The game to be tested is: Ginga Fukei Densetsu - Sapphire (NTSC-J), do not forget!
Thank you all and thank you @acris, for the patience once again.